Dons strikers Darren Mackie and Steve Lovell are out of Sunday's Scottish Cup showdown with Celtic.
Mackie, who was listed as a substitute, missed the 3-1 SPL defeat by Rangers at Ibrox due to a recurrent hamstring injury.
Dons manager Jimmy Calderwood fears Mackie could be out for more than a month.
Lovell scored the Aberdeen goal but then suffered a foot injury that could sideline him for two weeks.
Calderwood admitted the loss of both strikers is a massive blow ahead of the cup-tie, which the Dons must win to keep their season alive.
Calderwood said: "Darren got the injury in the first minute of our last session before going to Glasgow.
"He didn't even travel and be out for as much as six weeks.
"That is a massive blow, especially with Lovell struggling as well.
"He is in a in a lot of discomfort as well and it looks as if the injury will keep him out for two weeks."
Derek Young and Jamie Smith could ease the pain for the Dons by declaring themselves fit for Sunday's showdown.
Both are expected to return to full training this week.
Calderwood said: "Derek and Jamie can both play up front, so that would be a boost."
Celtic hammered the Dons 5-1 on their last league visit to Pittodrie but Calderwood is convinced his men can bounce back in the cup match.
"I doubt if Gordon Strachan will be coming here thinking they are in for an easy time." he said.
"Even though we lost 5-1 the last time, we still had some great chances at crucial stages of the game. "Darren Mackie missed a good one early on and we also let another go when it was only 2-0.
"If we get the first goal on Sunday it will be interesting to see how things work out.
"The players are also fired up because they taken a lot of flak in recent weeks, even though we've had key men missing for long spells.
"Sunday will be all about showing enough belief and determination and I can promise the fans we are in for a rip roaring cup tie."
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Dons strikers Darren Mackie and Steve Lovell are out of Sunday's Scottish Cup showdown with Celtic.
Mackie, who was listed as a substitute, missed the 3-1 SPL defeat by Rangers at Ibrox due to a recurrent hamstring injury.
Dons manager Jimmy Calderwood fears Mackie could be out for more than a month.
Lovell scored the Aberdeen goal but then suffered a foot injury that could sideline him for two weeks.
Calderwood admitted the loss of both strikers is a massive blow ahead of the cup-tie, which the Dons must win to keep their season alive.
Calderwood said: "Darren got the injury in the first minute of our last session before going to Glasgow.
"He didn't even travel and be out for as much as six weeks.
"That is a massive blow, especially with Lovell struggling as well.
"He is in a in a lot of discomfort as well and it looks as if the injury will keep him out for two weeks."
Derek Young and Jamie Smith could ease the pain for the Dons by declaring themselves fit for Sunday's showdown.
Both are expected to return to full training this week.
Calderwood said: "Derek and Jamie can both play up front, so that would be a boost."
Celtic hammered the Dons 5-1 on their last league visit to Pittodrie but Calderwood is convinced his men can bounce back in the cup match.
"I doubt if Gordon Strachan will be coming here thinking they are in for an easy time." he said.
"Even though we lost 5-1 the last time, we still had some great chances at crucial stages of the game. "Darren Mackie missed a good one early on and we also let another go when it was only 2-0.
"If we get the first goal on Sunday it will be interesting to see how things work out.
"The players are also fired up because they taken a lot of flak in recent weeks, even though we've had key men missing for long spells.
"Sunday will be all about showing enough belief and determination and I can promise the fans we are in for a rip roaring cup tie."